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The UNAIDS Executive Director stressed that AIDS has turned into one of the most serious challenges our planet has ever faced, ranking with climate change, international terrorism, and the threat of nuclear war as “one of the defining issues of our time.” “AIDS is forcing us to adopt new approaches, look at things differently, and transform the way we do things,” said UNAIDS Executive Director Peter Piot as he gave the 2007 Payne Lecture at Stanford University on May 9.