The report sets out the status of women’s, children’s and adolescents’ health, and on health systems and social and environmental determinants. Regional dashboards on 16 key indicators highlight where progress is being made or lagging. There is progress overall, but not at the level required to achieve the 2030 goals. There are some areas where progress has stalled or is reversing, namely neonatal mortality, gender inequalities and health in humanitarian settings. The report also highlights new evidence with a special focus on early childhood development as a foundation for health and well-being across the life course. There are new estimates on the causes of death in children older than 5 years; most are preventable. Each section of the report highlights strategic priorities, interventions and approaches that could help countries address challenges and accelerate progress.