Community-led responses (CLRs) are a vital pillar of the HIV response and central to achieving national and global targets, including the 30-80-60 commitments outlined in the 2021 Political Declaration on HIV and AIDS. These guidelines provide practical, step-by-step methods for costing and budgeting community-led responses (CLRs), tailored to the unique features of CLRs. They are designed for use by community-led organizations (CLOs), their partners, national governments, policy-makers, donors, and researchers involved in planning, implementing, financing or evaluating CLRs that address HIV.

UNAIDS uses ‘cost of inaction’ as an indicator of the negative impact on the lives of people and communities of not investing resources to end AIDS. This issue is particularly significant with regard to the provision of HIV and sexual and reproductive health and rights (SRHR) for young people in eastern and southern Africa.

The cost of inaction for young people is especially significant as the impact extends through most of their life. This report explores the costs of inaction in not realising the HIV and SRHR needs of young people in Kenya, Rwanda and Uganda, focusing on costs related to: 1) adolescent pregnancies, 2) HIV acquisition and 3) gender-based violation.

Using a cost of inaction approach, this report calculates the annual current cost of the inadequate provision of HIV and SRHR services to young people aged 15–24 years old in the three countries. This provides a foundation for alternative policies to be costed to address these gaps and a true cost–benefit analysis to be conducted.

This 2030 Prevention access framework focuses on one of those top-line targets, which covers primary prevention and requires that 90% of people in need of HIV prevention are using effective prevention options by 2030. This target is disaggregated into 15 second-line prevention targets for specific populations and programmes.

The 2030 Prevention Access Framework presents in greater detail the milestones and actions for achieving these targets––all of which are grounded in the three priorities of the Global AIDS Strategy: country-led, resilient and sustainable HIV responses; people-focused services, and community leadership.

Overall, the 2030 HIV prevention access push seeks to accelerate the use of innovations, expand use of the most cost-effective interventions, and confront the sustainability challenges facing the HIV response.

The Gender Assessment Tool for National HIV Responses (Gender Assessment Tool) is intended to assist countries in assessing their HIV epidemic, context and response through an intersectional gender lens, with the aim of strengthening gender-transformative, equitable and rights-based HIV responses. The 2025 tool places greater emphasis on cost-effectiveness, alignment with national plans, integration and sustainability. Together with a new costing tool and monitoring and evaluation plan template, it is designed to inform the development of country investment cases, funding requests to the Global Fund to Fight AIDS, Tuberculosis and Malaria, and other key national opportunities.

This report developed by UNAIDS and the United for Global Mental Health reviews and maps Global Fund investments in priority HIV and TB comorbidities in Grant Cycle 7 (GC7), including key non-communicable diseases (NCDs), cervical,  anorectal and other cancers, and mental health and substance use conditions.  It highlights how countries prioritize and are integrating health services and other interventions with HIV and TB programmes to advance person-centered approaches and to sustain HIV and TB responses. Analyzing approved grants from 103 countries, the report finds strong demand for integrated approaches, with 97% of countries prioritizing at least one comorbidity.  However, it also reveals major funding gaps, limited allocation compared to identified needs, and weaknesses in monitoring and accountability for integrated approaches, services and systems. The report concludes with practical recommendations to protect and scale evidence-informed and rights-based integrated systems, services and other interventions for addressing comorbidities, strengthen performance and outcome measurement, embed community engagement in decision-making, budgeting, performance monitoring and direct integrated service delivery, and reposition technical assistance, offering clear guidance for shaping sustained partnership, strategic investment, and collective commitment to strengthen systems for health and enhance integrated service delivery for more sustainable HIV and TB responses, and ensuring the health and well-being of people living with and at risk of HIV or TB.

This brief introduction to HIV phylogenetics is the first of three briefs on the phylogenetics of HIV. This brief introduces phylogenetics, explains how the genetic code can be read, and shows how the sequences can reveal insights into HIV biology and epidemiology. The second brief explores what we have learned from HIV phylogenetic studies and how HIV phylogenetics can and should be used to support public health programmes. The third brief discusses the ethical considerations of HIV phylogenetics, including the need for appropriate care and safeguards of sensitive information.