GENEVA, 8 March 2016—UNAIDS and telecommunications operator Orange have signed a memorandum of understanding to collaborate on a new project to strengthen links between health-care providers and people living with and affected by HIV through the use of mobile technology.

Mobile technology will be used to improve HIV services to ensure patient retention in care and treatment adherence and to help break down stigma and discrimination. Data will be collected and analyzed, gaps in services identified and action taken to improve the quality of health care for people living with and affected by HIV. The information collected will be anonymous and full confidentiality will be maintained.

“To achieve UNAIDS’ ambitious Fast-Track Targets by 2020, countries need to innovate,” said Michel Sidibé, Executive Director of UNAIDS. “This partnership with Orange will allow countries to benefit from state-of-the-art technology that is cost-effective and simple to use, to ensure they can provide the highest quality of services for people living with and affected by HIV.”  

UNAIDS and partners will use Orange Mobile Training EveryWhere (M-Tew), a web-based platform that has been designed to be fully integrated into health systems and implemented on a large scale. The M-Tew platform will enable health workers to communicate with people enrolled in care through text messages or by phone and voice messages. Health professionals will be able to send messages, conduct text or voice surveys to evaluate user perceptions on quality of services and answer questions through a virtual call centre.

The technology is simple to use and people enrolled in the project will only need a basic mobile phone and a 2G connection to send and receive messages, with no application to download and no Internet connection needed.

A four-month pilot phase will begin at the end of March 2016 in Abidjan, Côte d’Ivoire, which will involve 1000 people living with HIV who are enrolled in HIV treatment programmes. Participants in the pilot study will include people most affected by HIV, including 300 sex workers and men who have sex with men.

“President Alassane Ouattara has called for a reduction in HIV prevalence in Côte d’Ivoire to below 1% by 2020,” said Raymonde Goudou-Coffie, Minister of Health and Public Hygiene, Côte d’Ivoire. “We are committed to achieving this target and the new platform will help us Fast-Track our efforts to ensure we reach this ambitious goal.”

UNAIDS will collaborate on the project with the Ministry of Health and Public Hygiene of Côte d’Ivoire, the Autonomous District of Abidjan, Orange Côte d’Ivoire and civil society partners, including organizations of people living with HIV. After the pilot phase, the project will be rolled out more widely in health facilities across Abidjan, with plans to expand to other priority countries in the region. 

The partnership will advance efforts to Fast-Track the response to HIV towards ending the AIDS epidemic as a public health threat by 2030. To do this will require new innovations, front-loading investments over the next five years, reaching the UNAIDS 90–90–90 treatment target, expanding access to HIV prevention services and ensuring zero discrimination. 

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook, Twitter, Instagram and YouTube.

GENEVA, 2 March 2016—In just under 100 days’ time the 2016 United Nations General Assembly High-Level Meeting on Ending AIDS will take place in New York, United States of America. The meeting, being held from 8 to 10 June, will focus attention on the importance of accelerating the response to HIV over the next five years to set the world on course to end the AIDS epidemic by 2030 as part of the Sustainable Development Goals. 

The meeting will be convened by the President of the United Nations General Assembly, Mogens Lykketoft, and co-facilitated by Jürg Lauber, Permanent Representative of Switzerland to the United Nations, and Patricia Mwaba Kasese-Bota, Permanent Representative of Zambia to the United Nations.

“We are at a critical moment in the response to the AIDS epidemic,” said Mr Lykketoft. “All Member States must work together on a strong political declaration that will create the conditions needed to Fast-Track action and end the AIDS epidemic by 2030.”

The UNAIDS Fast-Track approach has a set of time-bound targets, including reducing the number of people newly infected with HIV from 2 million in 2014 to fewer than 500 000 in 2020, reducing the number of people dying from AIDS-related causes from 1.2 million in 2014 to fewer than 500 000 in 2020 and eliminating HIV-related discrimination.

“Over the next five years we have a fragile window of opportunity to shift gear and put the global HIV response firmly on the Fast-Track to end the AIDS epidemic,” said UNAIDS Executive Director Michel Sidibé. “This meeting will be critical to harnessing the momentum we have built and securing global commitment to break the epidemic for good.”

The world urgently needs to increase HIV investments now or risk reversing the major successes achieved in the first 15 years of the millennium. In 2015, an estimated US$ 21.7 billion was invested in the AIDS response in low- and middle-income countries. ​Investments need to increase,​ ​year on year from 2015, up to a peak of 40% higher in 202​0​, to reach the Fast-Track Targets​. Adopting the Fast-Track focus on location and population​ and ​reallocating resources to where they are most needed ​will ensure that people most affected by HIV are reached with life-changing HIV prevention and treatment services. ​Achieving all the Fast-Track Targets on time would ​ensure that estimated total resource needs begin to fall by 2021. Without these front-loaded investments the world risks prolonging the epidemic indefinitely​.

At the last United Nations General Assembly High-Level Meeting on AIDS, held in 2011, world leaders set an ambitious treatment target of 15 million people accessing antiretroviral therapy by the end of 2015. The United Nations Secretary-General, Ban Ki-moon, announced last year that this had been achieved and surpassed, with nearly 16 million people accessing antiretroviral therapy by mid-2015—double the number in 2011.

In the lead-up to the meeting in June, people living with and affected by HIV, civil society, the private sector, governments and regional bodies will come together at a series of meetings and events to reaffirm the priorities of the response to HIV.

The 100-day countdown to the United Nations General Assembly High-Level Meeting on Ending AIDS will be reflected on the UNAIDS website with daily messages from partners around the world on what ending AIDS means to them.

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook, Twitter, Instagram and YouTube.

Embrace diversity, understand and respect our differences, support one another

GENEVA, 25 February 2016—On 1 March, people around the world will be joining together to celebrate Zero Discrimination Day. This year’s theme is Stand Out and encourages everyone to stand for fair and just societies.

Discrimination remains widespread—gender, nationality, age, ethnic origin, sexual orientation or religion can all unfortunately be the basis for some form of discrimination. In only four out of 10 countries worldwide do equal numbers of girls and boys attend secondary school and 75 countries have laws that criminalize same-sex sexual relations.

“When the most marginalized and vulnerable face discrimination and abuse, all of us are diminished,” said United Nations Secretary-General Ban Ki-moon. “The United Nations is strongly committed to upholding human rights and dignity for all.”

Discrimination in health-care settings also continues to be widely reported. Imagine a young woman newly diagnosed with HIV being told by her doctor that she must be sterilized, a sex worker facing violence or abuse from a nurse, a disabled person denied access to proper advice about their sexual health, a gay man frightened of disclosing his sexuality to medical staff, a person who injects drugs dying after being refused treatment or a transgender person attempting suicide after being turned away from a clinic.

Health-care settings should be considered as safe and caring environments, however, such cases are happening too frequently throughout the world. Any obstacles that inhibit access to health-care facilities, including to testing, treatment and care services, must be removed. Access to health must be open to everyone. UNAIDS is partnering with the World Health Organization’s Global Health Workforce Alliance to develop a plan for action to end discrimination in health-care settings.

“On Zero Discrimination Day, stand out and stand together for the right to live free from stigma and discrimination,” said Michel Sidibé, Executive Director of UNAIDS. “By celebrating diversity, we can transform the future.”

On this year’s Zero Discrimination Day, people are being urged to value and embrace diversity and recognize the diverse set of talents and skills that each person brings—talents that enrich society and strengthen communities. Welcoming diversity in all its forms reinforces social cohesion and brings valuable benefits to societies around the world.

People can show their support for #zerodiscrimination through drawings, pictures, audio and video. Contributions can be posted on Facebook, Twitter and Instagram to illustrate personal stories about overcoming discrimination. Several artists, designers and illustrators have created original pieces providing their interpretation of zero discrimination—see @unaidsglobal on Instagram.

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook, Twitter, Instagram and YouTube.

PRETORIA/GENEVA, 2 December 2015—The Executive Director of UNAIDS, Michel Sidibé, has appointed South African First Lady Tobeka Madiba Zuma as UNAIDS Special Advocate for the Health of Women, Youth and Children. During a ceremony in Pretoria, South Africa, Mr Sidibé and Madam Zuma also signed a memorandum of understanding between UNAIDS and the Tobeka Madiba Zuma (TMZ) Foundation to strengthen collaboration between UNAIDS and the TMZ Foundation.

Madam Zuma will use her position as a UNAIDS Special Advocate to speak out on issues related to women’s sexual and reproductive health, especially on HIV prevention among adolescent girls and young women.

“I am delighted to be here with the First Lady of South Africa, Madam Zuma, to recognize her work to improve the lives of women and girls in South Africa, and to appoint her as UNAIDS Special Advocate for the Health of Women, Youth and Children,” said Mr Sidibé. “UNAIDS will continue to support her in her good work.”

Madam Zuma, as patron and founder of the TMZ Foundation, conducts extensive advocacy work on women’s health, with a focus on HIV, tuberculosis and breast and cervical cancer.

“I would like to thank UNAIDS for having worked with myself and the TMZ Foundation in recent years. I would also like to thank my husband, President Jacob Zuma, for taking bold steps to take us from denial to taking responsibility for the HIV epidemic,” said Madam Zuma. “I am happy and honoured, and pledge to use my position as First Lady of South Africa to raise awareness of these issues.”

Adolescent girls and young women in South Africa between the ages of 15 and 24 are at a much higher risk of HIV. It is estimated that new HIV infections among adolescent girls and young women in this age group account for a quarter of all new HIV infections in South Africa.

There are a range of biological and sociological factors that place young women and girls at higher risk of HIV infection, including early sexual debut, relationships with men much older than themselves, who may already be HIV-positive, and gender-based violence.
“Girls should have books, not babies,” remarked Madam Zuma, reflecting on the high prevalence of teenage pregnancy in the country.

The memorandum of understanding between UNAIDS and the TMZ Foundation will help to advance efforts in South Africa to improve the health of women, children and young people as part of the Sustainable Development Goals.

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook, Twitter, Instagram and YouTube.

The government’s commitment to ending the AIDS epidemic in South Africa has saved millions of lives

PRETORIA/GENEVA, 2 December 2015—The Executive Director of UNAIDS, Michel Sidibé, has commended the President of South Africa, Jacob Zuma, for his bold and visionary leadership in responding to HIV. During a meeting in Pretoria, Mr Sidibé and President Zuma discussed the country’s plans to end the AIDS epidemic in South Africa and how UNAIDS can support South Africa to advance its Fast-Track efforts to reach ambitious targets by 2020 and drive the epidemic into permanent decline.

“I appreciate the support that UNAIDS has given South Africa since Mr Sidibé first visited for World AIDS Day in 2009,” said President Zuma. “I remember we were together then, and he also came the following year, when we both tested for HIV in public. People said I was crazy, but I knew it had to be done to show people that they didn’t have to be afraid. He was with us then and he will be with us every step of the way to ending AIDS.”

During Mr Sidibé’s 2009 visit, President Zuma, who was newly elected as President earlier that year, made major policy announcements that sparked a new era in South Africa’s response to HIV.

“South Africa has completely changed the face of the epidemic,” said Mr Sidibé. “These changes are a result of President Zuma’s bold leadership, taking South Africa out of a dark period of despair, dependency and denial to a time of hope, ownership and full responsibility.”

South Africa now has the largest HIV treatment programme in the world, with more than 3 million people accessing treatment across the country. South Africa currently tests 10 million people annually for HIV and around 600 000 people newly started antiretroviral therapy in 2014 alone. These programmes have been supported by an unprecedented domestic investment in HIV―currently $1.8 billion a year― and the second largest in the world.

In 2014 President Zuma, Former President Bill Clinton, UNAIDS and other partners brokered a radical reduction in the cost of viral load testing, thereby making it possible for many more people to be tested and the effectiveness of their treatment to be monitored.

One of the biggest successes in South Africa’s response has been in stopping new HIV infections among children. In 2004, approximately 70 000 babies became newly infected with HIV; by 2014, that number had been reduced by almost 90%.

Fast-Track Strategy to reach people with HIV prevention and treatment and end the AIDS epidemic as a public health threat 

DURBAN/GENEVA, 1 December 2015—On World AIDS Day 2015, the Executive Director of UNAIDS, Michel Sidibé, has said that countries are on a countdown to ending their AIDS epidemics and that if swift and effective action is taken over the next five years, one by one they will break their epidemics so that they cannot rebound.

Mr Sidibé made the remarks as he joined the Deputy President of South Africa, Cyril Ramaphosa, at South Africa’s national World AIDS Day event, which was held in the Ugu District of KwaZulu-Natal Province on 1 December.

Introduced by Aaron Motsoaledi, the Minister of Health of South Africa, Mr Ramaphosa reflected on what World AIDS Day means to him: celebrating the courage of people living with HIV, evaluating the progress―or lack thereof―of the national AIDS response, recognizing partners and recommitting to the goal an HIV-free generation.

“This is the time for all of us to rise, act and protect. As a nation we must rise to the challenge and be confident that we can succeed,” said Mr Ramaphosa. “Yes, we will be triumphant and yes, we will make progress. As a nation and as individuals we must act to support and encourage others, and we must protect ourselves and those near to us.”

In his remarks, Mr Ramaphosa thanked Mr Sidibé for his role in encouraging South Africa to lead the charge towards ending AIDS.

“South Africa’s story is one of moving from denial to acceptance, from dependency to ownership and from despair to hope, with impressive results,” said Mr Sidibé. “South Africa has shown us not to be afraid of our future, but to shape it.”

Political leadership, community engagement and global solidarity have changed the face of the epidemic in South Africa.

In 2009, only a few hundred thousand people had access to antiretroviral therapy in South Africa. In just six years the number more than tripled, and in 2014 more than 3 million South Africans were accessing the life-changing treatment.

This was made possible by the government’s commitment and investment in the national response to HIV. South Africa invests US$ 1.8 billion dollars in the AIDS response—the second largest domestic investment in the world and the biggest in Africa. South Africa also secured a 53% reduction in the price of the provision of antiretroviral medicines. This has allowed more people to have access to treatment and has saved the country almost US$ 685 million over a two-year period.

The World AIDS Day event included participation by community champions, people living with HIV and a range of civil society organizations. A candle lighting ceremony was held to remember and honour loved ones lost to the AIDS epidemic.

“The world is facing a fragile five-year window of opportunity to break the epidemic and keep it from rebounding,” said Mr Sidibé. “We will not win against AIDS without communities. They are essential partners for the future success of the AIDS response.”

By supporting community organizations and strengthening local services, countries will be able to reach people who are still being left behind in the response to HIV. Ensuring access to HIV services for key populations will lead to healthier and more resilient societies. It will also significantly advance efforts to prevent new HIV infections and AIDS-related deaths, and to eliminate HIV-related stigma and discrimination.

UNAIDS estimates that a record 15.8 million people are now accessing treatment globally. However, 21.1 million people still do not have access to treatment and 17 million people do not know they are living with HIV. With attention to location and population, countries will be able to redistribute resources to improve access to HIV prevention, testing and treatment services and close the gaps towards ending the AIDS epidemic by 2030. 

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook, Twitter, Instagram and YouTube.

GENEVA/HARARE, 29 November 2015—At the opening of the 18th International Conference on AIDS and STIs in Africa (ICASA), taking place from 29 November to 4 December in Harare, Zimbabwe, UNAIDS has urged countries to further accelerate their response to HIV. The biennial conference is taking place at a defining moment in the response to the epidemic.

“Africa is on the brink of breaking the AIDS epidemic,” said UNAIDS Executive Director Michel Sidibé at the opening ceremony of the conference. “We have no time to lose. We have five years to Fast-Track the AIDS response so that the epidemic can’t rebound.”

UNAIDS is hosting several special sessions at ICASA, including one to discuss its new Fast-Track Strategy. Fast-Track involves front-loading investments in the AIDS response to reach an ambitious 90—90—90 treatment target by 2020. Reaching this target would see 90% of people living with HIV knowing their HIV status, 90% of people who know their HIV-positive status accessing treatment and 90% of people on treatment having suppressed viral loads. Reaching the Fast-Track Targets will also reduce new HIV infections by 75% and realize the vision of zero discrimination. The Fast-Track Strategy will see resources concentrated in locations with the greatest need and among populations at higher risk of HIV.

Other sessions organized by UNAIDS at ICASA include sessions on AIDS in emergency, conflict and humanitarian contexts and on optimizing the prevention of mother-to-child transmission of HIV through community engagement and mobilization.

The conference is taking place against a backdrop of great progress in the response to HIV, even though many challenges remain. Worldwide, 15.8 million people now have access to life-saving antiretroviral medicines, with more than 10 million people in sub-Saharan Africa accessing treatment. Based on the increased weight of scientific evidence concerning earlier treatment, the World Health Organization has released new guidance recommending that people be offered access to antiretroviral medicines as soon as possible after their HIV diagnosis regardless of their CD4 count.

In sub-Saharan Africa, the number of AIDS-related deaths in 2014 was 48% lower than in 2005, while new infections have declined by 41% since 2000. Scaled-up access to antiretroviral medicines in 21 high-priority countries has resulted in a fall of 48% between 2009 and 2014 in the number of children becoming infected with HIV. A number of countries including Ethiopia, Mozambique, Namibia, South Africa, Swaziland, Uganda and the United Republic of Tanzania have experienced declines of more than 60% in the number of children becoming infected with HIV.

However, major challenges still remain across the continent. The same progress is not being seen among young women and adolescent girls, for example, with young women aged 15-19 years old accounting for 71% of new HIV infections among this age group in sub-Saharan Africa.

In 2014, there were 36.9 million people living with HIV globally, 25.8 million of whom lived in sub-Saharan Africa. 

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook, Twitter, Instagram and YouTube.

Red Ribbon Award—honouring the best in community support to people living with and affected by HIV

1 December 2015—On this year’s World AIDS Day, UNAIDS and civil society partners, in collaboration with the organizers of the 21st International AIDS Conference, jointly announce a global call for nominations for the 2016 Red Ribbon Award. The award, which will be presented at the 21st International AIDS Conference, to be held in July 2016 in Durban, South Africa, honours community-based organizations for their contributions to the response to AIDS.

Community-based organizations have been instrumental in achieving the progress made so far towards ending the AIDS epidemic, which has seen new HIV infections fall by 35% since 2000 and AIDS-related deaths fall by 42% since the 2004 peak. Moreover, 15.8 million people living with HIV now have access to antiretroviral treatment.

Winning a Red Ribbon Award is highly respected by community-based organizations around the world. In 2014, more than 1000 nominations were received. The award not only brings a deserved spotlight on the most inspiring and innovative community responses, it also highlights the crucial importance of the community response to HIV and helps communities advocate for their involvement in the AIDS response with local, national and global leaders and decision-makers.

The biennial award is given to 10 organizations that have shown outstanding community leadership and action on HIV. The five award categories are:

• Good health and well-being (Sustainable Development Goal 3).
• Reduced inequalities (Sustainable Development Goal 10).
• Gender equality (Sustainable Development Goal 5).
• Just, peaceful and inclusive societies (Sustainable Development Goal 16).
• Global partnerships (Sustainable Development Goal 17).

These categories highlight the key elements of the UNAIDS Fast-Track Strategy targets to be met by 2020 to end the AIDS epidemic as a public health threat by 2030. Community-based organizations active in these categories have an important role to play in achieving the UNAIDS 90–90–90 treatment target by 2020 of 90% of people living with HIV knowing their status, 90% of people who know their HIV-positive are on treatment and 90% of people on treatment have suppressed viral loads.

Each winner of the award will receive US$ 10 000. Representatives of each winning body will present the work of their organization, their priorities, the challenges they face and their approaches to community engagement at the 21st International AIDS Conference.

Nominations will be accepted from 1 December 2015 to 14 February 2016. Nominations can be submitted online at www.redribbonaward.org, where further information can be found. Community-based organizations* working to halt and reverse the spread of HIV are encouraged to apply.

* Please note that only community-based organizations with an annual operating budget below US$ 200 000 should be nominated, and that organizations should have been established for more than one year at the time of nomination.

For more information, please visit www.redribbonaward.org.

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook, Twitter, Instagram and YouTube.

HARARE/GENEVA, 30 November 2015—The Clinton Health Access Initiative, Inc. (CHAI), UNAIDS, and UNITAID announce today three new agreements that could increase access to more sustainable HIV drug regimens at reduced prices, pending stringent regulatory approval and/or World Health Organization (WHO) pre-qualification.

These agreements have the potential to increase access to state-of-the-art HIV treatment regimens for people living with HIV in low- and middle- income countries. The regimens are expected to be more durable and produce fewer side effects than existing drugs and are included in the revised 2015 WHO consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection.

“Ensuring access to the most innovative and effective medicines for all people with HIV is essential in every country,” said Dr Margaret Chan, WHO Director-General. “I applaud CHAI and all the partners involved for these agreements, which move us one step closer to a world without AIDS.”

Under the first agreement, Aurobindo Pharma Limited has agreed to make generic dolutegravir (DTG) available for US$44 per patient per year, subject to regulatory approval. At this price, a DTG-containing regimen is comparable in price to the leading first-line regimen containing efavirenz (EFV). WHO now recommends DTG as an alternate first-line therapy in those intolerant of efavirenz. There are, as yet, insufficient data to recommend the use of DTG in women who are or wish to become pregnant or for people on treatment for tuberculosis; associated studies are currently underway.

The launch price agreement for DTG was made possible in part by the leadership of the Government of Kenya, which agreed to incorporate DTG into national treatment guidelines and begin providing DTG to suitable patients as soon as regulatory approval is received.

ViiV Healthcare licensed Aurobindo for generic DTG, enabling Aurobindo to file for tentative approval with the U.S. Food and Drug Administration (US FDA) for the single formulation in May 2015, making this the fastest filing for a generic antiretroviral following approval for the originator, which occurred in August 2013. As a part of today’s agreement, Aurobindo confirmed they will also file for a one-pill, once per day fixed-dose combination of DTG (combined with tenofovir disoproxyl fumarate and lamivudine) with the US FDA by Q3 2016. ViiV has also enabled other manufacturers to develop this fixed-dose combination through an earlier license provided to the Medicines Patent Pool.

"Bringing effective new HIV drugs to the millions of people who have still not initiated treatment is a big challenge in global health today," said UNITAID Executive Director Lelio Marmora. "The agreements announced between CHAI, UNAIDS and UNITAID with four manufacturing partners will be crucial to having game-changing medications included in WHO and national guidelines and brought to market more speedily."

Secondly, Mylan Laboratories Limited will file for US FDA tentative approval for an alternate first-line fixed-dose combination regimen in Q1 2016, and make it available for US$99 per patient per year, subject to regulatory approval. The new product, TLE400, contains tenofovir disoproxyl fumarate, lamivudine, and a reduced dose of efavirenz, and produced positive results in the ENCORE1 clinical study by the Kirby Institute at the University of New South Wales, Australia. Again, there are insufficient data to recommend this combination in TB patients or women who are pregnant, but related studies are either planned or underway. The new price marks an 8% decrease from current prices and could generate US$80-100 million in savings globally through 2020, if approved. To foster future competition and ensure supply security, the Kirby Institute and CHAI have agreed to make the study data available to companies seeking to develop other generic versions of TLE400.

“Ensuring access to high quality and affordable HIV drugs for all people living with the virus is a top priority for Zimbabwe,” said Honorable Dr. David Parirenyatwa, Minister of Health and Child Care in Zimbabwe. “We look forward to adopting TLE400 as our standard first-line treatment as soon as ongoing efficacy trials amongst pregnant women and TB patients are complete and it receives the appropriate regulatory approvals and is available. The clinical benefits and affordability make it the right choice for Zimbabwe, and we thank CHAI, UNAIDS, UNITAID and Mylan for helping to make this possible.”

Thirdly, a new partnership between Janssen: Pharmaceutical Companies of Johnson & Johnson and CHAI will facilitate the development and delivery of a heat-stable formulation of darunavir/ritonavir (DRV/r) to enhance its availability in resource-limited settings. For the first time, the revised 2015 WHO HIV treatment guidelines include DRV/r as an alternative component of second- or third-line HIV treatment regimens for adolescents and adults. DRV/r has a favorable resistance and tolerability profile compared to the current treatment options (lopinavir/ritonavir and atazanavir/ritonavir) and represents a once-daily regimen option for patients on second-line treatment. CHAI is also partnering with Hetero Drugs Limited to accelerate development of a generic version of DRV/r, and Hetero has committed to file for regulatory approval by Q3 2016. Together, these partnerships will aim to address development, manufacturing, and uptake barriers in order to expedite DRV/r availability in resource-limited settings. Janssen is the originator manufacturer for DRV; please see accompanying full Product Information for more details.

“As a global community, we need to ensure that the 15.8 million people currently on HIV treatment, and the millions more to be initiated on treatment over the next few years, have access to the best possible drugs to treat the disease and prevent further spread of the disease,” said Ira Magaziner, CEO of CHAI. “The agreements announced today are a great step forward in that effort, and CHAI is pleased that our continued collaboration with UNAIDS, UNITAID, WHO, the British Government, and industry partners has enabled this success.”

Together, these agreements have the potential to enhance access to optimal HIV treatment regimens and improve treatment outcomes for people in low-and middle-income countries. Increased access to treatment, retention in care, and improved treatment outcomes are critical to reaching the ambitious global 90-90-90 treatment targets, which aim to lay the foundation to end AIDS as a public health threat by 2030. The 90-90-90 targets require that by 2020, 90 percent of all people living with HIV will know their HIV status; 90 percent of all people with an HIV diagnosis will receive sustained antiretroviral therapy; and 90 percent of all people receiving antiretroviral therapy will achieve viral suppression.

“Access to life-changing HIV treatment should not be a lottery based on where you happen to live. To ensure equity and sustainability in the global AIDS response, continued collaboration with our industry and technical partners is essential to make optimal first-, second- and third-line HIV treatment regimens available and affordable for all people living with HIV,” said Michel Sidibé, UNAIDS Executive Director. “We welcome today’s agreements which we hope will improve treatment options available to all countries and help us to achieve our ambitious 90-90-90 treatment targets.”

CHAI and UNITAID are committed to an open, competitive marketplace for the products included in these agreements, and the suppliers included here are those that are closest to having product dossiers ready for stringent regulatory approval and/or WHO pre-qualification; any suppliers who are committed to developing these products to the same standards will also receive support.

CHAI’s contribution was made possible through the generous support of UNITAID and the UK Department for International Development.

Clinton Health Access Initiative, Inc.

The Clinton Health Access Initiative, Inc. (CHAI) is a global health organization committed to strengthening integrated health systems and expanding access to care and treatment in the developing world. CHAI’s solution-oriented approach focuses on improving market dynamics for medicines and diagnostics; lowering prices for treatment; accelerating access to life-saving technologies; and helping governments build the capacity required for high-quality care and treatment programs. For more information, please visit clintonhealthaccess.org and connect with us on Facebook and Twitter.

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook and Twitter.

UNITAID

UNITAID is an international organization founded in 2006 that finds new ways with partners to prevent, treat and diagnose HIV/AIDS, tuberculosis and malaria more quickly, more cheaply and more effectively. Its investments help turn groundbreaking ideas into effective solutions that enable partners to achieve the highest impact for those in need. Learn more at www.unitaid.org

An estimated 15.8 million people are now on HIV treatment, a doubling from five years ago, as countries adopt the UNAIDS Fast-Track Strategy using data to fine-tune delivery of HIV prevention and treatment services to reach people being left behind

GENEVA, 24 November 2015—Ahead of World AIDS Day 2015, UNAIDS has released a new report showing that countries are getting on the Fast-Track to end AIDS by 2030 as part of the Sustainable Development Goals. By adapting to a changing global environment and maximizing innovations, countries are seeing greater efficiencies and better results.

Progress in responding to HIV over the past 15 years has been extraordinary. By June 2015, UNAIDS estimates that 15.8 million people were accessing antiretroviral therapy, compared to 7.5 million people in 2010 and 2.2 million people in 2005. At the end of 2014, UNAIDS estimates that new HIV infections had fallen by 35% since the peak in 2000 and AIDS-related deaths have fallen by 42% since the 2004 peak.

“Every five years we have more than doubled the number of people on life-saving treatment,” said Michel Sidibé, Executive Director of UNAIDS. “We need to do it just one more time to break the AIDS epidemic and keep it from rebounding.”

The life-changing benefits of antiretroviral therapy mean that people living with HIV are living longer, healthier lives, which has contributed to an increase in the global number of people living with HIV. At the end of 2014, UNAIDS estimates that 36.9 million people were living with HIV. Once diagnosed, people need immediate access to antiretroviral therapy.

Countries are gearing up to double the number of people accessing HIV treatment by 2020. This Fast-Track approach will be instrumental in achieving the UNAIDS 90–90–90 treatment target of ensuring that 90% of people living with HIV know their HIV status, 90% of people who know their HIV-positive status are on treatment and 90% of people on treatment have suppressed viral loads.

“Today, we have more HIV prevention options than ever before. And with better data, we can become better matchmakers, finding the right prevention options for the right people,” said Mr Sidibé.

To end AIDS as a public health threat, an accelerated and more focused response is needed using better data to map and reach people in the places where the most new HIV infections occur. To support countries with this approach, UNAIDS has released a new report, Focus on location and population: on the Fast-Track to end AIDS by 2030, which gives examples of more than 50 communities, cities and countries that are using innovative approaches to reach more people with comprehensive HIV prevention and treatment services.

Through the responsible use of detailed national data sets, countries are able to focus at a more granular level, mapping where new HIV infections occur and where people need services most.  The report demonstrates how countries can redistribute resources to improve access to HIV prevention and treatment services. With the Fast-Track approach and front-loaded investments, gaps are closed faster and resources go further and from 2020 annual resource needs will begin to fall.

The report highlights how high-impact HIV prevention and treatment programmes, such as pre-exposure prophylaxis, voluntary medical male circumcision and sexual and reproductive health services, are being successfully implemented in various locations and for different populations, including adolescent girls and young women and their partners, pregnant women living with HIV, sex workers, transgender people, gay men and other men who have sex with men and people who inject drugs.

Examples of high-impact programmes are:

• A nationwide mapping in Kenya has helped to reach more female sex workers with a comprehensive package of HIV services and reduce the number new HIV infections among sex workers. Most dramatic has been the reduction in the incidence of sexually transmitted infections, from 27% among people screened in 2013 to just 3% in 2015.
• In Botswana, a policy change increased access to secondary school. Each additional year of secondary education was shown to reduce the cumulative risk of acquiring HIV by 8.1 percentage points.
• In the Islamic Republic of Iran in 2002–2003 only one prison provided methadone for just 100 prisoners dependent on opioids. By 2009, however, 142 prisons across all 30 provinces offered this vital harm reduction service, reaching 25 000 prisoners.
• A quarter of El Salvador’s transgender people live in the capital, San Salvador. In 2014, community centres were established in the country’s three largest cities to provide a comprehensive package of HIV prevention and health-care services tailored to the specific needs of this highly marginalized population. Within the first six months of 2015, these specialist services had reached a quarter of San Salvador’s transgender population.

These innovative programmes use national and subnational data and local knowledge from populations at higher risk of HIV to direct tailored HIV and related services to reach the people currently being left behind, resulting in greater impact at lower cost.

• Since July 2014 the community organization Colectivo Amigos contra el SIDA (CAS) has provided comprehensive HIV services in Guatemala City that are promoted on popular social networking websites and gay dating apps. The services are then provided through outreach activities in popular meeting places, such as parks, pedestrian walkways, saunas and nightclubs. These efforts have increased the reach of HIV prevention services by 61%, and the number of people tested increased by 32%. However, the map shows that coverage of services is still very low in many parts of the city.
• In the Blantyre district of Malawi, self-test kits were provided to 16 000 residents. Some 76% of residents self-tested and shared their results with a volunteer counsellor within one year.
• In 2012 and 2013, health facilities in Guangxi, China, began offering immediate initiation of antiretroviral therapy following diagnosis of HIV. As a result, the average time between diagnosis of HIV and initiation of treatment plummeted from 53 days to five days. Mortality also fell by approximately two thirds, from 27% to 10% during that same time period.
• Rwanda has integrated programmes to prevent mother-to-child transmission of HIV into maternal, neonatal and child health services and by 2014 had reduced new HIV infections among children by 88% compared to 2009.   

In the report UNAIDS identifies 35 Fast-Track countries that account for 90% of new HIV infections. Focusing on location and population and programmes that deliver the greatest impact will reap huge benefits by 2030: 21 million AIDS-related deaths averted; 28 million new HIV infections averted; and 5.9 million new infections among children averted.

“Everyone has the right to a long and healthy life,” said Mr Sidibé. “We must take HIV services to the people who are most affected, and ensure that these services are delivered in a safe, respectful environment with dignity and free from discrimination.”

The report shows that areas with fewer numbers of people living with HIV and lower HIV prevalence are more likely to have discriminatory attitudes than areas that have more cases of HIV. This seemingly contradictory result is explained by education and understanding about HIV usually being higher in countries where HIV is more prevalent and where more people are receiving treatment. However, these discriminatory attitudes make it more difficult for people in low-prevalence areas to come forward to seek HIV services for fear of stigma and reprisals.   

Adopting the UNAIDS Fast-Track approach through strong leadership and investment within the communities, cities and countries most affected, the AIDS epidemic can be ended by 2030 as part of the Sustainable Development Goals. 

Read the publication on ISSUU

• Part 1 (Foreword - Conclusions)
• Part 2a (Where services are needed - Lesotho)
• Part 2b (Malawi - References)

UNAIDS

The Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. UNAIDS unites the efforts of 11 UN organizations—UNHCR, UNICEF, WFP, UNDP, UNFPA, UNODC, UN Women, ILO, UNESCO, WHO and the World Bank—and works closely with global and national partners towards ending the AIDS epidemic by 2030 as part of the Sustainable Development Goals. Learn more at unaids.org and connect with us on Facebook, Twitter, Instagram and YouTube.